The use of indole as a spectrophotometric assay substrate for toluene dioxygenase

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Laboratory evolution of toluene dioxygenase to accept 4-picoline as a substrate.

We are using directed evolution to extend the range of dioxygenase-catalyzed biotransformations to include substrates that are either poorly accepted or not accepted at all by the naturally occurring enzymes. Here we report on the oxidation of a heterocyclic substrate, 4-picoline, by toluene dioxygenase (TDO) and improvement of the enzyme's activity by laboratory evolution. The biotransformatio...

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ژورنال

عنوان ژورنال: FEMS Microbiology Letters

سال: 1985

ISSN: 0378-1097

DOI: 10.1016/0378-1097(85)90397-0